Erectile Dysfunction: Causes and Treatments. KROGER. With each use of edex®, alternate the side of the penis and vary the site of the injection (Figure L). edex® Cartridge 6 Pack contains one reusable edex® injection device, six single-dose, dual-chamber cartridges, six ½-inch, 29-gauge (0.33 mm × 12.7 mm) needles, and twelve alcohol swabs. Hypotension occurred in less than 1% of patients treated with edex®. Edex Powder for solution for injection 10mcg Drug Medication Dosage information. This leads to expansion of lacunar spaces and entrapment of blood by compressing the venules against the tunica albuginea, a process referred to as the corporal veno-occlusive mechanism. Please read carefully before using. Buy Edex (Alprostadil) Description: Edex (Alprostadil) is a prostaglandin (PGE-1) used to treat impotence. Due to the fact that PGE1 is primarily metabolized in the lung, the observed differences between hepatically impaired subjects and healthy volunteers were not anticipated; the mechanism responsible for the observed discrepancies is not known. Cardiovascular Risk Related to Underlying Medical Conditions. PGE1 entering the systemic circulation is rapidly and extensively metabolized in the lungs with a first-pass pulmonary elimination of 60 to 90% of PGE1. Allow 5 to 10 seconds to completely inject the dose. Keep all regular medical appointments, and have regular checkups to monitor the effectiveness and safety of this medication. edex® is not indicated for use in women or pediatric patients. Edex 40mcg Cartridge Kit - 6 Pack Unfortunately our full catalog may not be displayed in your state. Among the 60% (141/233) of patients who entered the placebo-controlled phase, an erection sufficient for sexual intercourse was achieved in 73% (103/141) of patients following edex® injection compared to 13% (18/141) of patients following placebo injection. Men with penile implants, severe penile curvature, or those who have been advised not to engage in sexual activity should not use edex®. Note: Always attach the needle to the injection device before inserting the cartridge into the injection device. Properly discard this product when it is expired or no longer needed. 2. edex® solution should be used immediately after reconstitution. In most cases, these reactions were attributed to faulty injection technique. SAFEWAY. The edex® cartridges contain a solid layer or cake of dry white powder approximately 3/8” in thickness. After reconstitution, the edex® injection device is used to administer the intracavernous injection of alprostadil. Once the injection device is dry, place it in the carrying case. Adults—1.25 to 60 micrograms (mcg) as a single dose once a day. Use of intracavernous edex® offers no protection from the transmission of sexually transmitted or blood-borne diseases. Do not inject more than one dose within 24 hours. The deliverable amount of alprostadil in these dilutions is 5 mcg/mL, 10 mcg/mL, 20 mcg/mL, or 40 mcg/mL, respectively, because some drug is absorbed onto the vial and syringe. Caverject is an injectable medication used to treat erectile dysfunction by directing blood flow to the penis. If there is a partial response, the dose may be increased by 2.5 mcg to a dose of 5 mcg and then in increments of 5 to 10 mcg, depending upon erectile response, until the dose that produces an erection suitable for intercourse and not exceeding a duration of 1 hour is reached. Alprostadil is an endogenous substa Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. The patient should follow the instructions in the patient information pamphlet to limit the possibility of bacterial contamination. The terminal half-life of PGE1 in healthy volunteers was calculated to be around 9 to 11 minutes which is consistent with that reported in the literature (8 minutes). 19. edex ® is a penile injection used to treat erectile dysfunction (ED) caused by conditions affecting nerves, blood vessels, emotions, and/or a combination of factors. The patient may expect an erection to occur within 5 to 20 minutes. Treatment can be resumed if the penile abnormality subsides. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Discontinuation of therapy due to a side effect in clinical trials was required in approximately 9% of patients treated with edex® and in <1% of patients treated with placebo. Pick up the cartridge and wipe the tip of the cartridge with an alcohol swab. Precontracted isolated preparations of the human corpus cavernosum, corpus spongiosum and cavernous artery are relaxed by alprostadil. If you have questions, ask your pharmacist. Erectile response was measured by the Buckling Test to assess axial penile rigidity. edex 40 MCG in 1 ML Cartridge injectable is a powder medicine that comes with a sterile liquid for mixing it. US residents can call their local poison control center at 1-800-222-1222. Alprostadil is an endogenous substance known as prostaglandin E1 (PGE1). 69. If you have any questions, ask your doctor or pharmacist. Call your doctor if you notice any redness, lumps, swelling, tenderness or curvature of the erect penis. Note: Individuals who are sexually active should be counseled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus (HIV). Among the 71% (81/114) of patients who entered the placebo-controlled phase, an erection sufficient for sexual intercourse was achieved in 74% (60/81) of patients following edex® injection compared to 7% (6/81) of patients following placebo injection. Generic Name: alprostadil After intracavernous injection of 20 mcg of edex® in patients with erectile dysfunction, the terminal half-lives (t½) of 15-keto-PGE0 and PGE0 were calculated to be 40.9 ± 16.5 minutes and 63.2 ± 31.1 minutes, respectively. Study 2: Two hundred thirty-three men with a mean age of 59.8 years (range 23 to 74 years) were enrolled in the first phase. Not all photos of the drug may be displayed. Among the 60% (139/233) of patients who entered the open-label treatment phase, the mean rate of response with an erection sufficient for intercourse was 85.3% through six months. In patients treated with edex® for up to 24 months, local bleeding, hematoma, and ecchymosis were observed in 15%, 5%, and 4% of patients, respectively. The reconstituted cartridge is designed for one use only and should be discarded after use. Your medication may look different. The photos shown are samples only In Canada - Call your doctor for medical advice about side effects. A higher incidence of prolonged erections was found in younger patients (<40 years), non-diabetic patients, and patients with psychogenic etiology of erectile dysfunction (See WARNINGS). Careful and continuous follow-up of the patient while in the self-injection program must be exercised. The reconstituted solution may initially appear cloudy due to small air bubbles. Do not touch the exposed needle (Figure B). Access Coupon. If there is a response, then there should be at least a 1-day interval before the next dose is given. Careful instruction in proper patient handling and injection techniques may minimize the potential for needle breakage. Be sure to use only the dose prescribed by your doctor. Sterile Powder and Diluent Do not discard this swab; you will need to use it later. Do not use the solution if it remains cloudy, contains precipitates, or is discolored. One chamber of the cartridge contains alprostadil, alfadex and lactose as a sterile, pyrogen-free powder. As with any injection, infection is possible. The patient is strongly encouraged to go to the nearest emergency room if his personal physician is not available. Medication name. Therefore, choose an injection site on the other side of the penis from the site of the last dose, using a different area each time. In placebo-controlled studies, penile pain was reported by 31% of patients after edex® and by 9% of patients after placebo injection. The following local adverse reactions were reported in studies including 1,065 patients treated with edex® for up to two years. Alprostadil also attenuates presynaptic noradrenaline release in the corpus cavernosum which is essential for the maintenance of a flaccid and non-erect penis. In placebo-controlled studies, 3% of patients treated with edex® and <1% of patients treated with placebo reported prolonged erections greater than four hours. Note: The plunger pushes the rubber stoppers forward; the rubber stoppers cannot be pulled back with the plunger. In the event of an overdose, supportive therapy according to the presence of other symptoms is recommended. Medically reviewed by Drugs.com. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: This is not a complete list of possible side effects. To prepare the drug solution, slowly push the plunger until the two gray rubber stoppers touch (Figure H). 80% off Offer Details: Edex Injection - FDA prescribing information, side effects . A common side effect of edex® is mild to moderate pain during injection. Overall differences in safety were not observed between these geriatric patients and younger patients. Position the needle horizontally and gently insert the needle into the selected injection site until the needle is almost completely inserted into the penis (Figure M). edex® is indicated for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology. The single-dose, dual-chamber cartridge should be reconstituted only when it is certain that the patient is ready to administer the drug. This medication is not recommended for use in men with penile implants. Endogenous PGE1 is derived from dihomo-gamma-linolenic acid, a fatty acid found within the phospholipids of cellular membranes. Get Edex Coupon Card by print, email or text and save up to 75% off Edex at the pharmacy. If there is no response, then the next higher dose may be given within 1 hour. If the dosage prescribed is less than 1 mL of edex® solution, excess solution will be expelled through the needle as the plunger is pushed and the upper rim of the top stopper reaches the correct volume mark for the prescribed dose. 8. Inform your doctor if your condition persists or worsens (for example, if the drug does not produce an erection or it becomes more difficult to get an erection). Loading... View more photos. 2) Regular follow-up of patients, with careful examination of the penis at the start of therapy and at regular intervals (e.g. Alprostadil did not produce damage to chromosomes or the mitotic apparatus in the in vivo rat micronucleus test. Adults—1.25 to 60 micrograms (mcg) as a single dose once a day. Please read this information carefully before you prepare the edex® solution. Before using, check this product visually for particles or discoloration. During the subsequent two-week double-blind, cross-over phase, patients self-injected edex® or placebo at home. 49. Many people using this medication do not have serious side effects. The other chamber contains 1.075 mL of sterile 0.9% sodium chloride. Edex 10mcg Cartridge Kit - 2 Pack Unfortunately our full catalog may not be displayed in your state. Each needle and cartridge should be used only once. 1. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. If the needle is bent, replace it with a new needle. Patients should be aware of possible side effects of therapy with edex®; the most frequently occurring is penile pain during and/or after injection, usually mild to moderate in severity. edex®, administered by intracavernous injection in doses ranging from 1 to 40 mcg per injection for periods up to 24 months, has been evaluated in clinical trials for safety in over 1,065 patients with erectile dysfunction. The intracavernous injection must be done under sterile conditions. The mean duration of erection following edex® was 59.0 minutes compared to 7.6 minutes following placebo. With use of up to 24 months, penile pain was reported at least once by 29% of patients during injection, 35% of patients during erection, and by 30% of patients after erection. The above value exceeded cardiac output indicating extensive and rapid elimination of PGE1 in the lungs and/or blood. Mix edex® just prior to injection. The patient must visit the physician's office for regular checkups for assessment of the therapeutic benefit and safety of treatment with edex®. Grasping the head of the penis with your thumb and forefinger, stretch it lengthwise along your thigh so that you can clearly see the selected injection site. Before injecting each dose, clean the injection site with rubbing alcohol. Note: Always attach the needle to the injection device before inserting the cartridge into the injection device. Attach the plunger to the injection device by turning the blue portion of the plunger clockwise until tight (Figure G). 21. A ½ inch, 27 to 30 gauge needle is generally recommended for the intracavernous injection. Prolonged erections greater than four hours in duration occurred in 4% of all patients treated up to 24 months. (alprostadil for injection) The reconstituted edex® cartridge and needle are intended for single use only and should be discarded after use. If you have any of these conditions, consult your doctor. 10. 22. edex® Cartridge 6 Pack contains enough supplies for six injections. Cost With Our Coupon $ 179. Excess solution will be expelled through the needle. Remove the seal from the base of the needle. A normal cake may appear cracked or crumbled. In this study, the pulmonary extraction efficiency of alprostadil ranged from subnormal (11%) to normal (90%), with an overall mean of 67%. The injection of edex® can induce a small amount of bleeding at the site of injection. edex® should be used no more than 3 times per week, with at least 24 hours between each use. The instructions for preparation of the edex® solution should be carefully followed. Beginning with a 40 mcg bolus intravenous dose, the frequency of drug-related systemic adverse events increased in a dose-dependent manner, characterized mainly by facial flushing. JLA FORUMS - … The manufacturer recommends that this medication be used no more than 3 times a week with at least 1 day between each dose. Remove the cartridge from the injection device by turning the blue portion of the plunger counterclockwise. In clinical trials, concomitant use of agents such as antihypertensive drugs, diuretics, antidiabetic agents (including insulin), or nonsteroidal anti-inflammatory drugs had no apparent effect on the efficacy or safety of edex®. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. Erections that last more than 6 hours can cause serious damage to the penile tissue and may result in permanent impotence. The overall incidence of penile fibrosis, including Peyronie's disease, reported in clinical studies up to 24 months with edex® was 7.8%. It is important to change the location of the injection site with each dose to avoid problem areas under the skin. The reusable edex® injection device is for use only with the single-dose, dual-chamber cartridges and needles included in the edex® Cartridge 2 Pack or 6 Pack. Some of these conditions include sickle cell anemia or trait, leukemia, and tumor of the bone marrow (multiple myeloma). edex® (alprostadil for injection), administered by intracavernous injection in doses ranging from 1 to 40 mcg per injection for periods up to 24 months, has been evaluated in clinical trials for safety in over 1,065 patients with erectile dysfunction. The recommended frequency of injection is no more than 3 times weekly, with at least 24 hours between each dose. If either is present, do not use the liquid. A patient information pamphlet is included in each package of edex® cartridges. The mean Cmax value of PGE1 in renally impaired patients was 37% lower as compared to that in healthy volunteers whereas mean Cmax values of 15-keto-PGE0 and PGE0 in these patients increased 104% and 145%, respectively, as compared to those in healthy volunteers. As with all prescription medicines, the patient should not allow anyone else to use his medicine. Hemodynamic changes, manifested as increases or decreases in blood pressure and pulse rate, were observed during clinical studies but did not appear to be dose-dependent. Therefore, the use of such combinations is not recommended. The patient should be instructed not to reuse or to share needles or cartridges. Do not use a bent needle to inject this medication. Edex has the same component medication as does Caverject (prostaglandin E1 or PGE1) Trimix is another injectable preparation that can be used for the treatment of erectile dysfunction in men. Pamphlet is included in the dose prescribed by your doctor, adverse were! 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